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Role of cannabinoid CB(2) receptors in glucose homeostasis in rats.
Eur J Pharmacol. 2007 Apr 20;
Authors: Bermudez-Silva FJ, Sanchez-Vera I, Suárez J, Serrano A, Fuentes E, Juan-Pico P, Nadal A, Rodríguez de Fonseca F
Here we show that the activation of cannabinoid CB(2) receptors improved glucose tolerance after a glucose load. Blockade of cannabinoid CB(2) receptors counteracted this effect, leading to glucose intolerance. Since blockade of cannabinoid CB(1) receptors mimics the actions of cannabinoid CB(2) receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid CB(1) and CB(2) receptors. We also describe the presence of both cannabinoid CB(1) and CB(2) receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis.
PMID: 17499236 [PubMed - as supplied by publisher]
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